What to Expect: Your First Ketamine Therapy Appointment
Most patients searching for ketamine therapy have never done it before. This page walks through exactly what happens from your first phone call to your first session, so you know what you’re walking into.
The Process, Step by Step
The Phone Consult (free, ~15 minutes)
You call us or book online. A clinical team member will:
- Ask about your symptoms and treatment history
- Explain how ketamine therapy works at Hydrate
- Confirm whether you are a likely candidate
- Schedule your in-clinic medical evaluation
No pressure to commit. The phone consult is the lowest-cost way to get your real questions answered.
Medical Evaluation
This is a separate appointment, typically 60 minutes, at our Asheville clinic. A licensed clinician will:
- Review your medical history, current medications, and mental health history
- Discuss your prior treatments and what has and has not worked
- Explain the protocol they recommend (infusion or KAP, single session or series)
- Walk you through the experience, side effects, and aftercare
- Screen for contraindications
If you are cleared for treatment, you and your clinician set a treatment plan together. You can start the first session that day in some cases, or schedule for a later date.
Bring:
- Photo ID
- A list of current medications
- Prior treatment records if available
- Your insurance card (for HSA/FSA documentation, not because we bill insurance)
The Day of Your First Session
Plan for 1.5 to 2 hours at the clinic.
Before you arrive:
- Eat a light meal 1 to 2 hours before
- Drink plenty of water
- Wear comfortable clothes
- Arrange a ride home (you cannot drive after)
- Stop any medications your clinician told you to pause (typically benzodiazepines)
At the clinic:
- Check in at the front desk
- A nurse takes vital signs (blood pressure, heart rate, oxygen saturation)
- You settle into a private treatment room with a reclining chair
- The IV is started (small needle, similar to a routine blood draw)
- The infusion begins at a controlled rate
During the infusion:
- 40 to 60 minutes of active infusion
- You will feel effects within 5 to 15 minutes
- Most patients experience dissociation: a sense of being separated from one’s body, altered perception of time, mild visual changes
- A nurse is present or close by throughout. You can pause or stop at any time.
- You can listen to music or sit in silence. Some patients prefer eye covers.
After the infusion:
- 30 minutes of recovery time in a quiet space
- The dissociative effects fade within an hour
- Your nurse re-checks vital signs and clears you to leave
- Your driver takes you home
The First 24 Hours
Plan to rest. Most patients describe the day after a ketamine session as:
- Mildly tired or “stretchy” in the morning
- Notably calm
- Sometimes clearer in mood by the evening
You can return to normal activity the next day. Avoid heavy lifting, intense workouts, and major decisions for 24 hours.
The Treatment Series
Most patients begin with 4 to 6 sessions over 2 to 3 weeks. Each session builds on the prior one. By session 3 or 4, many patients begin to notice changes in mood, sleep, or symptom intensity.
We check in between sessions. If something is not working, we adjust.
Maintenance
After the initial series, your clinician will recommend a maintenance schedule based on your response. Common patterns:
- Every 2 weeks (for patients with intensive symptom return)
- Every 4 to 6 weeks (most common)
- Every 8 to 12 weeks (for stable responders)
Some patients eventually taper off treatment. Some maintain dosing indefinitely. Both are reasonable paths based on clinical response.
What If Something Doesn’t Feel Right?
You can pause or stop a session at any time. Our nursing team is ER-trained, which means rapid response to side effects is built into how they work.
If you notice unusual side effects between sessions (mood changes, sleep disruption, physical symptoms), call us. We take patient communication seriously.
Frequently Asked Questions
How will I feel during the infusion?
Most patients describe dissociation as interesting or peaceful. A minority find it uncomfortable. The medical setting and clinical support help most patients move through any initial discomfort.
Can I bring someone with me?
Yes. A support person can accompany you to the appointment, though they typically wait in the lobby during the infusion. They are required if you need a ride home.
Will I remember the session?
Yes. Patients are conscious throughout, though the dissociative effects can blur some details. Most patients remember the broad arc of the experience.
Will it hurt?
The IV start is the only mildly uncomfortable part. Ketamine itself does not cause pain during infusion.
What if I cry or feel emotional?
Common. Ketamine often brings emotional material to the surface. Our nursing team and your clinician are prepared to support you. Many patients describe emotional release during a session as part of why the treatment works.
Can I work after?
No driving. Most patients take the rest of the day off. You can resume normal activity the day after.
Ready?
Book a free 15-minute phone consult. No commitment, no pressure.
Visit: Hydrate Medical Asheville, 190 Hendersonville Rd Suite 30, Asheville, NC 28803
Ketamine therapy is not appropriate for every patient. A medical evaluation by a licensed clinician is required prior to treatment. Individual results vary.